Monocytes are a group of immune cells that originate in bone marrow and are released into peripheral blood, where they circulate for several days. They belong to the mononuclear-phagocyte system, which also include macrophages, dendritic cells, and their bone-marrow precursors. Monocytes represent 5–10% of peripheral leucocytes .
Monocytes have been divided into three subtypes based on relative surface expression of LPS co-receptor CD14 and FCγIII receptor CD16. The most predominant of the three, termed “classical monocytes”, express high levels of CD14 on their surface, are devoid of surface CD16, and account for approximately 80% of the total monocyte population. The remaining 20% express CD16 and have been further classified into two subtypes. The more abundant “nonclassical monocytes”, are characterized by very low expression of surface CD14 and high levels of CD16, whereas the third monocyte subtype, called “intermediate monocytes”, express high levels of both the receptors.
Monocytes have been divided into three subtypes based on relative surface expression of LPS co-receptor CD14 and FCγIII receptor CD16. The most predominant of the three, termed “classical monocytes”, express high levels of CD14 on their surface, are devoid of surface CD16, and account for approximately 80% of the total monocyte population. The remaining 20% express CD16 and have been further classified into two subtypes. The more abundant “nonclassical monocytes”, are characterized by very low expression of surface CD14 and high levels of CD16, whereas the third monocyte subtype, called “intermediate monocytes”, express high levels of both the receptors.
