Delayed bone age

• CONSTITUTIONAL
o Familial
o IUGR
• METABOLIC

o Hypopituitarism
o Hypothyroidism
o Hypogonadism (Turner syndrome)
o Cushing disease, steroid therapy
o Diabetes mellitus
o Rickets
o Malnutrition
o Irradiation of brain (for cerebral tumor / ALL)
• SYSTEMIC DISEASE
o Congenital heart disease
o Renal disease
o GI disease: celiac disease, Crohn disease, ulcerative colitis
o Anemia
o Bone marrow transplantation (<5 age="age" br="br" of="of" years="years">• SYNDROMES
o Trisomies
o Noonan disease
o Cornelia de Lange syndrome
o Cleidocranial dysplasia
o Lesch-Nyhan disease
o Metatrophic dwarfism